Guest Post: Stick To Your Workout With Sulbutiamine – Stay Fit!

Here at we want you to love working out just as much as we do! We want you to enjoy your newly bought fitness equipment (and not just enjoy the amazing deals you got here), and to get plenty of use out of them! We’ve shared previous posts on how to find that motivation to exercise, but if you still are not fully motivated, here’s a great supplement our guest author shares that should help get you there! 

What is Sulbutiamine?

Sulbutiamine is a synthetic derivative of vitamin B12. It carries a very interesting history. In the 1800’s, a disease called Beriberi was running rampant through Japan. The two main symptoms of Beriberi are lethargy and fatigue. In other words, Beriberi completely zapped people of energy, and eventually led to more serious complications. Japan formed a committee with one purpose, finding a treatment for the disease. They came up with Sulbutiamine. People treated with Sulbutiamine regained their energy and recovered from the disease. Since then, scientists have studied Sulbutiamine in more detail, and have discovered it can benefit healthy individuals.

ExerciseHow Will Sulbutiamine Help My Workout?

Sulbutiamine provides people with energy and motivation through a couple mechanisms of action. One of these mechanisms is an effect on the dopaminergic receptors in the brain. 1 When your brain releases dopamine, it must bind to specific receptors, called dopaminergic receptors. Sulbutiamine increases the amount of D1 dopaminergic binding sites in your brain. This increases the effectiveness of dopamine.

Dopamine is a neurotransmitter. Your brain cells communicate with each other by firing neurotransmitters across synaptic connections. There are neurotransmitters for every function you can think of. Some neurotransmitters regulate appetite, some regulate memory and learning, others regulate mood and motivation.

Dopamine plays a very important role in our brain’s reward system. It provides people with energy, boosts mood, and motivates us to perform certain activities. When we engage in an activity that releases dopamine, our brain actively seeks to re-engage in that activity.

An extreme example of this is Cocaine. Cocaine effects our dopamine differently than Sulbutiamine. Cocaine does two things. It causes our brain cells to create greater amounts of dopamine. And it prevents our dopamine receptors from breaking down the dopamine. This floods our brain’s synapses with dopamine and creates a very noticeable effect. The profound effect cocaine has on our dopamine system makes it very addictive.

Luckily, Sulbutiamine isn’t addicting. It has a very mild effect on our dopamine system. It barely tips the scales in the direction we want. It doesn’t throw the scales against the wall like cocaine does. But the small tip it does provide improves our mood, supplies us with energy, and motivation. Sulbutiamine will give you the energy and motivation you need to hit the gym. And your brain will associate working out with the effects Sulbutiamine provides. This will make it much easier to follow a strict workout regimen.

How Safe Is Sulbutiamine?

Unlike cocaine, Sulbutiamine is very safe. At therapeutic doses of 850mg per day, only mild skin allergies were reported. There is only one report of serious complications, and this was caused by chronic abuse. 2 The patient in question was taking over 2 grams every day and had bipolar disorder. Unless you abuse Sulbutiamine, mild skin allergies are all you will have to worry about.

I recommend that you don’t take more than 600mg at one time. They generally come in 200mg capsules. But you can also purchase it in powder form. Taking your dose roughly one hour before your workout is preferable. It takes between 20-45 minutes for Sulbutiamine to take effect.

Please visit What Are Nootropics if you want to learn more about Sulbutiamine.


1. Evidence for a modulatory effect on sulbutiamine on glutamatergic and dopaminergic cortical transmissions, Neurosci Lett, 2000 Sep 29;

2. Douzenis A, Michopoulos I, Lykouras L (2006). “Sulbutiamine, an ‘innocent’ over the counter drug, interferes with therapeutic outcome of bipolar disorder”. World J Biol Psychiatry 7 (3): 183–5. doi:10.1080/15622970500492616. PMID 16861144.